PENGARUH KADAR D-DIMER, KREATININ SERUM, DAN JUMLAH LIMFOSIT ABSOLUT TERHADAP DERAJAT KEPARAHAN PASIEN COVID-19 KOMORBID CHRONIC KIDNEY DISEASE
ABSTRACT COVID-19 is an infectious respiratory disease caused by infection SARS-CoV-2. Abnormal kidney function is associated with increased morbidity and mortality in COVID-19 patients. D-dimer levels, serum creatinine, and ALC can be used as markers of inflammation to determine the severity of COV...
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| Formato: | UMS Journal (OJS) |
| Idioma: | eng |
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Universitas Muhammadiyah Surakarta
2023
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| Acesso em linha: | https://journals2.ums.ac.id/index.php/biomedika/article/view/3307 |
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| author | Maharani, Rahmi Annisa Nurhyatun, Evi Harioputro, Dhani Redhono |
| author_facet | Maharani, Rahmi Annisa Nurhyatun, Evi Harioputro, Dhani Redhono |
| author_sort | Maharani, Rahmi Annisa |
| collection | OJS |
| description | ABSTRACT
COVID-19 is an infectious respiratory disease caused by infection SARS-CoV-2. Abnormal kidney function is associated with increased morbidity and mortality in COVID-19 patients. D-dimer levels, serum creatinine, and ALC can be used as markers of inflammation to determine the severity of COVID-19 comorbid chronic kidney disease (CKD). However, there are not many studies on this subject. This study aims to determine the impact of D-dimer, serum creatinine, and Absolute Lymphocyte Count (ALC) on the severity of COVID-19 comorbid CKD. This study uses an analytic observational method with a cross sectional approach from medical record data. The study population included COVID-19 patients with comorbid CKD at RS X Surakarta, who was examined for D-dimer levels, serum creatinine, and absolute lymphocyte counts, using purposive sampling and sample consisted of 53 patients. Bivariate analysis using Spearman’s Rank test obtained p value of D-dimer, serum creatinine, absolute lymphocyte counts 0,002; 0,042; 0,455. Multivariate analysis using multiple logistics regression showed that D-dimer OR=28,521 and serum creatinine OR=5,650, with a Nagelkerke R Square value of 0,338. There is an impact of D-dimer and serum creatinine levels on the severity of COVID-19 patients with CKD.
ABSTRAK
COVID-19 adalah penyakit pernapasan menular akibat infeksi virus SARS-CoV-2. Penyakit ginjal merupakan salah satu komorbid terbanyak pasien COVID-19, fungsi ginjal yang tidak normal berhubungan dengan peningkatan angka morbiditas dan mortalitas pasien COVID-19. Penelitian ini bertujuan untuk mengetahui pengaruh antara D-dimer, kreatinin serum, dan jumlah limfosit absolut terhadap derajat keparahan COVID-19 dengan komorbid chronic kidney disease (CKD). Penelitian ini menggunakan metode observasional analitik dengan pendekatan cross sectional dari data rekam medis. Populasi penelitian meliputi pasien COVID-19 dengan komorbid CKD di RS X Surakarta yang dilakukan pemeriksaan kadar D-dimer, kreatinin serum, dan jumlah limfosit absolut dengan teknik sampling purposive sampling didapatkan sebanyak 53 sampel. Analisis bivariat menggunakan uji korelasi Rank Spearman dan didapatkan nilai p D-dimer, kreatinin serum, jumlah limfosit absolut dengan keparahan COVID-19 masing-masing 0,002; 0,042; 0,455. Analisis multivariat menggunakan uji regresi logistik berganda dan didapatkan nilai OR D-dimer dan kreatinin serum masing-masing 28,521 dan 5,650 dengan nilai Nagelkerke R Square 0,338. Kesimpulan penelitian ini bahwa Kadar D-dimer dan kreatinin serum berpengaruh terhadap derajat keparahan pasien COVID-19 dengan komorbid CKD. |
| format | UMS Journal (OJS) |
| id | oai:ojs2.journals2.ums.ac.id:article-3307 |
| institution | Universitas Muhammadiyah Surakarta |
| language | eng |
| publishDate | 2023 |
| publisher | Universitas Muhammadiyah Surakarta |
| record_format | ojs |
| spelling | oai:ojs2.journals2.ums.ac.id:article-3307 PENGARUH KADAR D-DIMER, KREATININ SERUM, DAN JUMLAH LIMFOSIT ABSOLUT TERHADAP DERAJAT KEPARAHAN PASIEN COVID-19 KOMORBID CHRONIC KIDNEY DISEASE Maharani, Rahmi Annisa Nurhyatun, Evi Harioputro, Dhani Redhono Chronic Kidney Disease (CKD) COVID-19 D-dimer Absolute Lymphocyte Count (ALC), Serum Creatinine Jumlah Limfosit Absolut Kreatinin Serum ABSTRACT COVID-19 is an infectious respiratory disease caused by infection SARS-CoV-2. Abnormal kidney function is associated with increased morbidity and mortality in COVID-19 patients. D-dimer levels, serum creatinine, and ALC can be used as markers of inflammation to determine the severity of COVID-19 comorbid chronic kidney disease (CKD). However, there are not many studies on this subject. This study aims to determine the impact of D-dimer, serum creatinine, and Absolute Lymphocyte Count (ALC) on the severity of COVID-19 comorbid CKD. This study uses an analytic observational method with a cross sectional approach from medical record data. The study population included COVID-19 patients with comorbid CKD at RS X Surakarta, who was examined for D-dimer levels, serum creatinine, and absolute lymphocyte counts, using purposive sampling and sample consisted of 53 patients. Bivariate analysis using Spearman’s Rank test obtained p value of D-dimer, serum creatinine, absolute lymphocyte counts 0,002; 0,042; 0,455. Multivariate analysis using multiple logistics regression showed that D-dimer OR=28,521 and serum creatinine OR=5,650, with a Nagelkerke R Square value of 0,338. There is an impact of D-dimer and serum creatinine levels on the severity of COVID-19 patients with CKD. ABSTRAK COVID-19 adalah penyakit pernapasan menular akibat infeksi virus SARS-CoV-2. Penyakit ginjal merupakan salah satu komorbid terbanyak pasien COVID-19, fungsi ginjal yang tidak normal berhubungan dengan peningkatan angka morbiditas dan mortalitas pasien COVID-19. Penelitian ini bertujuan untuk mengetahui pengaruh antara D-dimer, kreatinin serum, dan jumlah limfosit absolut terhadap derajat keparahan COVID-19 dengan komorbid chronic kidney disease (CKD). Penelitian ini menggunakan metode observasional analitik dengan pendekatan cross sectional dari data rekam medis. Populasi penelitian meliputi pasien COVID-19 dengan komorbid CKD di RS X Surakarta yang dilakukan pemeriksaan kadar D-dimer, kreatinin serum, dan jumlah limfosit absolut dengan teknik sampling purposive sampling didapatkan sebanyak 53 sampel. Analisis bivariat menggunakan uji korelasi Rank Spearman dan didapatkan nilai p D-dimer, kreatinin serum, jumlah limfosit absolut dengan keparahan COVID-19 masing-masing 0,002; 0,042; 0,455. Analisis multivariat menggunakan uji regresi logistik berganda dan didapatkan nilai OR D-dimer dan kreatinin serum masing-masing 28,521 dan 5,650 dengan nilai Nagelkerke R Square 0,338. Kesimpulan penelitian ini bahwa Kadar D-dimer dan kreatinin serum berpengaruh terhadap derajat keparahan pasien COVID-19 dengan komorbid CKD. Universitas Muhammadiyah Surakarta 2023-08-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://journals2.ums.ac.id/index.php/biomedika/article/view/3307 10.23917/biomedika.v15i2.3307 Biomedika; Vol 15, No 2 (2023): Biomedika Agustus 2023; 117 - 126 2541-2582 2085-8345 eng https://journals2.ums.ac.id/index.php/biomedika/article/view/3307/876 Copyright (c) 2023 Biomedika https://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Chronic Kidney Disease (CKD) COVID-19 D-dimer Absolute Lymphocyte Count (ALC), Serum Creatinine Jumlah Limfosit Absolut Kreatinin Serum Maharani, Rahmi Annisa Nurhyatun, Evi Harioputro, Dhani Redhono PENGARUH KADAR D-DIMER, KREATININ SERUM, DAN JUMLAH LIMFOSIT ABSOLUT TERHADAP DERAJAT KEPARAHAN PASIEN COVID-19 KOMORBID CHRONIC KIDNEY DISEASE |
| title | PENGARUH KADAR D-DIMER, KREATININ SERUM, DAN JUMLAH LIMFOSIT ABSOLUT TERHADAP DERAJAT KEPARAHAN PASIEN COVID-19 KOMORBID CHRONIC KIDNEY DISEASE |
| title_full | PENGARUH KADAR D-DIMER, KREATININ SERUM, DAN JUMLAH LIMFOSIT ABSOLUT TERHADAP DERAJAT KEPARAHAN PASIEN COVID-19 KOMORBID CHRONIC KIDNEY DISEASE |
| title_fullStr | PENGARUH KADAR D-DIMER, KREATININ SERUM, DAN JUMLAH LIMFOSIT ABSOLUT TERHADAP DERAJAT KEPARAHAN PASIEN COVID-19 KOMORBID CHRONIC KIDNEY DISEASE |
| title_full_unstemmed | PENGARUH KADAR D-DIMER, KREATININ SERUM, DAN JUMLAH LIMFOSIT ABSOLUT TERHADAP DERAJAT KEPARAHAN PASIEN COVID-19 KOMORBID CHRONIC KIDNEY DISEASE |
| title_short | PENGARUH KADAR D-DIMER, KREATININ SERUM, DAN JUMLAH LIMFOSIT ABSOLUT TERHADAP DERAJAT KEPARAHAN PASIEN COVID-19 KOMORBID CHRONIC KIDNEY DISEASE |
| title_sort | pengaruh kadar d dimer kreatinin serum dan jumlah limfosit absolut terhadap derajat keparahan pasien covid 19 komorbid chronic kidney disease |
| topic | Chronic Kidney Disease (CKD) COVID-19 D-dimer Absolute Lymphocyte Count (ALC), Serum Creatinine Jumlah Limfosit Absolut Kreatinin Serum |
| topic_facet | Chronic Kidney Disease (CKD) COVID-19 D-dimer Absolute Lymphocyte Count (ALC), Serum Creatinine Jumlah Limfosit Absolut Kreatinin Serum |
| url | https://journals2.ums.ac.id/index.php/biomedika/article/view/3307 |
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