Detection Of Bordetella Pertussis the Cause of Whooping Cough: A Narrative Review
Bordetella Perussis transmits pertussis disease, known as whooping cough, through airborne secretions from the respiratory tract. The bacteria then attach to the epithelial cilia of the respiratory tract of other hosts. One of the main virulence factors produced by Bordetella pertussis is pertussis...
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| Format: | UMS Journal (OJS) |
| Language: | eng |
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Universitas Muhammadiyah Surakarta
2024
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| Online Access: | https://journals2.ums.ac.id/index.php/biomedika/article/view/2799 |
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| author | Adiyaksa, Jongga Tjampakasari, Conny Riana |
| author_facet | Adiyaksa, Jongga Tjampakasari, Conny Riana |
| author_sort | Adiyaksa, Jongga |
| collection | OJS |
| description | Bordetella Perussis transmits pertussis disease, known as whooping cough, through airborne secretions from the respiratory tract. The bacteria then attach to the epithelial cilia of the respiratory tract of other hosts. One of the main virulence factors produced by Bordetella pertussis is pertussis toxin (PTx) which in its inactivated form is the main component of all acellular pertussis vaccines. In addition, PTx also activates several receptors and can affect various signaling pathways independent of ADP ribosylation and adenylate cyclase. PTx has been used in many research fields due to its strong ADP-ribosylation properties. To detect PTx Bordetella pertussis can use diagnostic tests such as serology test. Aim of this literary study is to determine the types of examinations for the detection of Bordetella pertussis. This study used a narrative review method sourced from searches on PubMed and ScienceDirect. The results of this search showed various types of Bordetella pertussis detection, including detection by culture, serology, and PCR. In conclusion, culture is still recommended to assess vaccine efficacy and future vaccine development, serological tests are one of the main diagnostic procedures in cases of unvaccinated adolescents and adults using specific B. pertussis proteins as antigens, in the presence of increased IgA or IgG titers against the toxin pertussis (PT) and filamentous hemmagglutinin (FHA). PCR as a diagnostic tool for pertussis in neonates and children. |
| format | UMS Journal (OJS) |
| id | oai:ojs2.journals2.ums.ac.id:article-2799 |
| institution | Universitas Muhammadiyah Surakarta |
| language | eng |
| publishDate | 2024 |
| publisher | Universitas Muhammadiyah Surakarta |
| record_format | ojs |
| spelling | oai:ojs2.journals2.ums.ac.id:article-2799 Detection Of Bordetella Pertussis the Cause of Whooping Cough: A Narrative Review Adiyaksa, Jongga Tjampakasari, Conny Riana Bordetella pertussis Whooping cough Filamentous hemmagglutinin (FHA) Pertussis toxin Bordetella Perussis transmits pertussis disease, known as whooping cough, through airborne secretions from the respiratory tract. The bacteria then attach to the epithelial cilia of the respiratory tract of other hosts. One of the main virulence factors produced by Bordetella pertussis is pertussis toxin (PTx) which in its inactivated form is the main component of all acellular pertussis vaccines. In addition, PTx also activates several receptors and can affect various signaling pathways independent of ADP ribosylation and adenylate cyclase. PTx has been used in many research fields due to its strong ADP-ribosylation properties. To detect PTx Bordetella pertussis can use diagnostic tests such as serology test. Aim of this literary study is to determine the types of examinations for the detection of Bordetella pertussis. This study used a narrative review method sourced from searches on PubMed and ScienceDirect. The results of this search showed various types of Bordetella pertussis detection, including detection by culture, serology, and PCR. In conclusion, culture is still recommended to assess vaccine efficacy and future vaccine development, serological tests are one of the main diagnostic procedures in cases of unvaccinated adolescents and adults using specific B. pertussis proteins as antigens, in the presence of increased IgA or IgG titers against the toxin pertussis (PT) and filamentous hemmagglutinin (FHA). PCR as a diagnostic tool for pertussis in neonates and children. Universitas Muhammadiyah Surakarta 2024-04-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://journals2.ums.ac.id/index.php/biomedika/article/view/2799 10.23917/biomedika.v16i1.2799 Biomedika; Vol 16, No 1 (2024): Biomedika Februari 2024; 1 - 10 2541-2582 2085-8345 eng https://journals2.ums.ac.id/index.php/biomedika/article/view/2799/1226 Copyright (c) 2024 Biomedika https://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Bordetella pertussis Whooping cough Filamentous hemmagglutinin (FHA) Pertussis toxin Adiyaksa, Jongga Tjampakasari, Conny Riana Detection Of Bordetella Pertussis the Cause of Whooping Cough: A Narrative Review |
| title | Detection Of Bordetella Pertussis the Cause of Whooping Cough: A Narrative Review |
| title_full | Detection Of Bordetella Pertussis the Cause of Whooping Cough: A Narrative Review |
| title_fullStr | Detection Of Bordetella Pertussis the Cause of Whooping Cough: A Narrative Review |
| title_full_unstemmed | Detection Of Bordetella Pertussis the Cause of Whooping Cough: A Narrative Review |
| title_short | Detection Of Bordetella Pertussis the Cause of Whooping Cough: A Narrative Review |
| title_sort | detection of bordetella pertussis the cause of whooping cough a narrative review |
| topic | Bordetella pertussis Whooping cough Filamentous hemmagglutinin (FHA) Pertussis toxin |
| topic_facet | Bordetella pertussis Whooping cough Filamentous hemmagglutinin (FHA) Pertussis toxin |
| url | https://journals2.ums.ac.id/index.php/biomedika/article/view/2799 |
| work_keys_str_mv | AT adiyaksajongga detectionofbordetellapertussisthecauseofwhoopingcoughanarrativereview AT tjampakasariconnyriana detectionofbordetellapertussisthecauseofwhoopingcoughanarrativereview |