POTENSI INHIBITOR SENYAWA PADA SUKUN (Artocarpus altilis) TERHADAP PROTEIN POLY (ADP-RIBOSE) POLYMERASE 2 (PARP2) PADA KANKER OVARIUM DENGAN MODEL MOLECULAR DOCKING: Inhibitor Potency of Compounds in Breadfruit (Artocarpus altilis) Against Protein Poly (ADP-Ribose) Polymerase 2 (PARP2) in Ovarian Cancer with The Molecular Docking Model
ABSTRACT Ovarian cancer is the third leading cause of cancer death in Indonesia. The mechanism of cancer needs to be understood to create drugs that play a role in inhibiting the development of cancer cells. PARP is a prime protein in cancer cell development. PARP is a target of chemotherapy, namely...
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Language: | eng |
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Universitas Muhammadiyah Surakarta
2023
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author | Saputra, I Putu Bayu Agus Sukanty, Ni Made Wiasty Arjita, I Putu Deddy Adnyana, I Gede Angga |
author_facet | Saputra, I Putu Bayu Agus Sukanty, Ni Made Wiasty Arjita, I Putu Deddy Adnyana, I Gede Angga |
author_sort | Saputra, I Putu Bayu Agus |
collection | OJS |
description | ABSTRACT
Ovarian cancer is the third leading cause of cancer death in Indonesia. The mechanism of cancer needs to be understood to create drugs that play a role in inhibiting the development of cancer cells. PARP is a prime protein in cancer cell development. PARP is a target of chemotherapy, namely through its inhibition by 3-aminobenzamide compounds. Treatment using natural ingredients is safer than using synthetic drugs. Breadfruit (Artocarpus altilis) is a plant that grows in Indonesia. It is efficacious because it contains many compounds used in the manufacture of various types of drugs. The PARP receptor (3KCZ) was examined for the value of binding affinity with the flavonoid derivative ligands contained in breadfruit (Artocarpus altilis) using the help of the software Pyrx version 0.8. The test results showed tamoxifen (-8 kcal/mol), quercetin (-8 kcal/mol), cyclocommunal (-9.6 kcal/mol), morusin (-6.7 kcal/mol), and cyclomulberrin (-9 kcal /mol) have a lower binding affinity value compared to 3-aminobenzamide (-6.6 kcal/mol) which is the native ligand of PARP. These results prove that the flavonoid-derived compounds in breadfruit can potentially act as PARP inhibitors in ovarian cancer cells.
ABSTRAK
Kanker ovarium merupakan kanker penyebab kematian ketiga terbesar di Indonesia. Mekanisme kanker sangat perlu dipahami untuk menciptakan obat yang berperan menghambat perkembangan sel kanker. PARP merupakan protein yang berperan penting pada perkembangan sel kanker. PARP telah terbukti dapat menjadi target kemoterapi, yaitu melalui penghambatannya oleh senyawa 3-aminobenzamide. Pengobatan menggunakan bahan alami lebih aman dibandingkan penggunaan obat sintetis. Sukun (Artocarpus altilis) merupakan tumbuhan yang tumbuh di Indonesia yang berkhasiat karena mengandung senyawa yang dapat dimanfaatkan dalam pembuatan berbagai jenis obat. Reseptor PARP (3KCZ) dilihat nilai binding affinity dengan ligan turunan flavonoid yang terkandung pada sukun (Artocarpus altilis) menggunakan bantuan softwere pyrx versi o,8. Hasil uji menunjukkan senyawa tamoxifen (-8 kcal/mol), quercetin (-8 kcal/mol), cyclocommunal (-9,6 kcal/mol), morusin (-6,7 kcal/mol), dan cyclomulberrin (-9 kcal/mol) memiliki nilai binding affinity yang lebih kecil dibandingkan dengan 3-aminobenzamide (-6,6 kcal/mol) yang merupakan native ligan dari PARP. Hasil ini membuktikan bahwa senyawa-senyawa turunan flavonoid pada sukun dapat berpotensi sebagai inhibitor PARP pada sel kanker ovarium. |
format | UMS Journal (OJS) |
id | oai:ojs2.journals2.ums.ac.id:article-1748 |
institution | Universitas Muhammadiyah Surakarta |
language | eng |
publishDate | 2023 |
publisher | Universitas Muhammadiyah Surakarta |
record_format | ojs |
spelling | oai:ojs2.journals2.ums.ac.id:article-1748 POTENSI INHIBITOR SENYAWA PADA SUKUN (Artocarpus altilis) TERHADAP PROTEIN POLY (ADP-RIBOSE) POLYMERASE 2 (PARP2) PADA KANKER OVARIUM DENGAN MODEL MOLECULAR DOCKING: Inhibitor Potency of Compounds in Breadfruit (Artocarpus altilis) Against Protein Poly (ADP-Ribose) Polymerase 2 (PARP2) in Ovarian Cancer with The Molecular Docking Model Saputra, I Putu Bayu Agus Sukanty, Ni Made Wiasty Arjita, I Putu Deddy Adnyana, I Gede Angga Ovarian Cancer PARP Molecular Docking 3-Aminobenzamide Breadfruit Kanker Ovarium sukun ABSTRACT Ovarian cancer is the third leading cause of cancer death in Indonesia. The mechanism of cancer needs to be understood to create drugs that play a role in inhibiting the development of cancer cells. PARP is a prime protein in cancer cell development. PARP is a target of chemotherapy, namely through its inhibition by 3-aminobenzamide compounds. Treatment using natural ingredients is safer than using synthetic drugs. Breadfruit (Artocarpus altilis) is a plant that grows in Indonesia. It is efficacious because it contains many compounds used in the manufacture of various types of drugs. The PARP receptor (3KCZ) was examined for the value of binding affinity with the flavonoid derivative ligands contained in breadfruit (Artocarpus altilis) using the help of the software Pyrx version 0.8. The test results showed tamoxifen (-8 kcal/mol), quercetin (-8 kcal/mol), cyclocommunal (-9.6 kcal/mol), morusin (-6.7 kcal/mol), and cyclomulberrin (-9 kcal /mol) have a lower binding affinity value compared to 3-aminobenzamide (-6.6 kcal/mol) which is the native ligand of PARP. These results prove that the flavonoid-derived compounds in breadfruit can potentially act as PARP inhibitors in ovarian cancer cells. ABSTRAK Kanker ovarium merupakan kanker penyebab kematian ketiga terbesar di Indonesia. Mekanisme kanker sangat perlu dipahami untuk menciptakan obat yang berperan menghambat perkembangan sel kanker. PARP merupakan protein yang berperan penting pada perkembangan sel kanker. PARP telah terbukti dapat menjadi target kemoterapi, yaitu melalui penghambatannya oleh senyawa 3-aminobenzamide. Pengobatan menggunakan bahan alami lebih aman dibandingkan penggunaan obat sintetis. Sukun (Artocarpus altilis) merupakan tumbuhan yang tumbuh di Indonesia yang berkhasiat karena mengandung senyawa yang dapat dimanfaatkan dalam pembuatan berbagai jenis obat. Reseptor PARP (3KCZ) dilihat nilai binding affinity dengan ligan turunan flavonoid yang terkandung pada sukun (Artocarpus altilis) menggunakan bantuan softwere pyrx versi o,8. Hasil uji menunjukkan senyawa tamoxifen (-8 kcal/mol), quercetin (-8 kcal/mol), cyclocommunal (-9,6 kcal/mol), morusin (-6,7 kcal/mol), dan cyclomulberrin (-9 kcal/mol) memiliki nilai binding affinity yang lebih kecil dibandingkan dengan 3-aminobenzamide (-6,6 kcal/mol) yang merupakan native ligan dari PARP. Hasil ini membuktikan bahwa senyawa-senyawa turunan flavonoid pada sukun dapat berpotensi sebagai inhibitor PARP pada sel kanker ovarium. Universitas Muhammadiyah Surakarta 2023-02-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://journals2.ums.ac.id/index.php/biomedika/article/view/1748 10.23917/biomedika.v15i1.1748 Biomedika; Vol 15, No 1 (2023): Biomedika Februari 2023; 43-52 2541-2582 2085-8345 eng https://journals2.ums.ac.id/index.php/biomedika/article/view/1748/535 https://creativecommons.org/licenses/by/4.0 |
spellingShingle | Ovarian Cancer PARP Molecular Docking 3-Aminobenzamide Breadfruit Kanker Ovarium sukun Saputra, I Putu Bayu Agus Sukanty, Ni Made Wiasty Arjita, I Putu Deddy Adnyana, I Gede Angga POTENSI INHIBITOR SENYAWA PADA SUKUN (Artocarpus altilis) TERHADAP PROTEIN POLY (ADP-RIBOSE) POLYMERASE 2 (PARP2) PADA KANKER OVARIUM DENGAN MODEL MOLECULAR DOCKING: Inhibitor Potency of Compounds in Breadfruit (Artocarpus altilis) Against Protein Poly (ADP-Ribose) Polymerase 2 (PARP2) in Ovarian Cancer with The Molecular Docking Model |
title | POTENSI INHIBITOR SENYAWA PADA SUKUN (Artocarpus altilis) TERHADAP PROTEIN POLY (ADP-RIBOSE) POLYMERASE 2 (PARP2) PADA KANKER OVARIUM DENGAN MODEL MOLECULAR DOCKING: Inhibitor Potency of Compounds in Breadfruit (Artocarpus altilis) Against Protein Poly (ADP-Ribose) Polymerase 2 (PARP2) in Ovarian Cancer with The Molecular Docking Model |
title_full | POTENSI INHIBITOR SENYAWA PADA SUKUN (Artocarpus altilis) TERHADAP PROTEIN POLY (ADP-RIBOSE) POLYMERASE 2 (PARP2) PADA KANKER OVARIUM DENGAN MODEL MOLECULAR DOCKING: Inhibitor Potency of Compounds in Breadfruit (Artocarpus altilis) Against Protein Poly (ADP-Ribose) Polymerase 2 (PARP2) in Ovarian Cancer with The Molecular Docking Model |
title_fullStr | POTENSI INHIBITOR SENYAWA PADA SUKUN (Artocarpus altilis) TERHADAP PROTEIN POLY (ADP-RIBOSE) POLYMERASE 2 (PARP2) PADA KANKER OVARIUM DENGAN MODEL MOLECULAR DOCKING: Inhibitor Potency of Compounds in Breadfruit (Artocarpus altilis) Against Protein Poly (ADP-Ribose) Polymerase 2 (PARP2) in Ovarian Cancer with The Molecular Docking Model |
title_full_unstemmed | POTENSI INHIBITOR SENYAWA PADA SUKUN (Artocarpus altilis) TERHADAP PROTEIN POLY (ADP-RIBOSE) POLYMERASE 2 (PARP2) PADA KANKER OVARIUM DENGAN MODEL MOLECULAR DOCKING: Inhibitor Potency of Compounds in Breadfruit (Artocarpus altilis) Against Protein Poly (ADP-Ribose) Polymerase 2 (PARP2) in Ovarian Cancer with The Molecular Docking Model |
title_short | POTENSI INHIBITOR SENYAWA PADA SUKUN (Artocarpus altilis) TERHADAP PROTEIN POLY (ADP-RIBOSE) POLYMERASE 2 (PARP2) PADA KANKER OVARIUM DENGAN MODEL MOLECULAR DOCKING: Inhibitor Potency of Compounds in Breadfruit (Artocarpus altilis) Against Protein Poly (ADP-Ribose) Polymerase 2 (PARP2) in Ovarian Cancer with The Molecular Docking Model |
title_sort | potensi inhibitor senyawa pada sukun artocarpus altilis terhadap protein poly adp ribose polymerase 2 parp2 pada kanker ovarium dengan model molecular docking inhibitor potency of compounds in breadfruit artocarpus altilis against protein poly adp ribose polymerase 2 parp2 in ovarian cancer with the molecular docking model |
topic | Ovarian Cancer PARP Molecular Docking 3-Aminobenzamide Breadfruit Kanker Ovarium sukun |
topic_facet | Ovarian Cancer PARP Molecular Docking 3-Aminobenzamide Breadfruit Kanker Ovarium sukun |
url | https://journals2.ums.ac.id/index.php/biomedika/article/view/1748 |
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