DECREASED SEX HORMONE-BINDING GLOBULIN (SHBG) SERUM LEVEL IN POLYCYSTIC OVARIAN SYNDROME PATIENTS (PCOS): Penurunan Kadar Sex Hormone-Binding Globulin Serum (SHBG) pada Pasien Polycystic Ovarian Syndrome Patients (PCOS)
ABSTRACT Classic symptoms of PCOS including irregular menstruation, high serum androgen concentration, hirsutism, and infertility or subfertility. Low serum sex hormon binding globulin (SHBG) may cause increase of free serum androgen which in turn may cause ovarian dysfunction and clinical symptoms...
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| Format: | UMS Journal (OJS) |
| Language: | eng |
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Universitas Muhammadiyah Surakarta
2023
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| Online Access: | https://journals2.ums.ac.id/index.php/biomedika/article/view/1744 |
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| author | Zahra, Azalia Talitha Saleh, M. Irsan Hafy, Zen Effendi, Yusuf Maritska, Ziske Liberty, Iche Andriyani |
| author_facet | Zahra, Azalia Talitha Saleh, M. Irsan Hafy, Zen Effendi, Yusuf Maritska, Ziske Liberty, Iche Andriyani |
| author_sort | Zahra, Azalia Talitha |
| collection | OJS |
| description | ABSTRACT
Classic symptoms of PCOS including irregular menstruation, high serum androgen concentration, hirsutism, and infertility or subfertility. Low serum sex hormon binding globulin (SHBG) may cause increase of free serum androgen which in turn may cause ovarian dysfunction and clinical symptoms associated with hyperandrogenism. This study aims to look the difference of serum SHBG concentration in PCOS patients and healthy control in Palembang, South Sumatra. This was a case-control study involved 36 PCOS patients and 36 healthy controls. Patient serum was collected and SHBG concentration was conducted using ELISA according to manufacturer instruction. Median serum SHBG concentration in PCOS case group was 152.524 nmol/L (min. 5.756 nmol/L, max. 1539.383 nmol/L). meanwhile, median serum SHBG concentration in control group was 971.449 nmol/L (min. 114.479 nmol/L, max. 1944.036 nmol/L). The difference was found to be statistically significant, with p < 0.001 according to Mann-Whitney test. It is to be concluded that serum SHBG concentration is significantly lower in PCOS patient group compared to healthy control.
ABSTRAK
Gejala khas PCOS berupa berupa haid tidak teratur, kadar androgen serum yang tinggi, hirsutisme, dan infertilitas atau subfertilitas. Kadar sex hormon binding globulin serum yang rendah menyebabkan peningkatan kadar androgen bebas di serum yang dapat menyebabkan disfungsi ovarium dan gejala klinis yang terkait hiperandrogenisme. Penelitian ini bertujuan untuk melihat perbedaan kadar SHBG serum pada pasien PCOS dan kontrol sehat di Palembang, Sumatra Selatan. Penelitian ini menggunakan metode case control dengan sampel 36 pasien PCOS dan 36 kontrol sehat. Serum darah pasien diambil dan kadar SHBG diperiksa menggunakan ELISA sesuai instruksi pembuat. Kadar SHBG median pada kelompok kasus PCOS adalah 152,524 nmol/L (min. 5,756 nmol/L, maks. 1539,383 nmol/L). sementara itu, kadar SHBG median pada kelompok kontrol adalah 971,449 nmol/L (min. 114,479 nmol/L, maks. 1944,036 nmol/L). Perbedaan tersebut bermakna secara statistik dengan p< 0,001 dengan uji Mann-Whitney. Dapat disimpulkan bahwa kadar SHBG serum pada subjek dengan PCOS lebih rendah secara bermakna dibandingkan dengan kelompok kontrol. |
| format | UMS Journal (OJS) |
| id | oai:ojs2.journals2.ums.ac.id:article-1744 |
| institution | Universitas Muhammadiyah Surakarta |
| language | eng |
| publishDate | 2023 |
| publisher | Universitas Muhammadiyah Surakarta |
| record_format | ojs |
| spelling | oai:ojs2.journals2.ums.ac.id:article-1744 DECREASED SEX HORMONE-BINDING GLOBULIN (SHBG) SERUM LEVEL IN POLYCYSTIC OVARIAN SYNDROME PATIENTS (PCOS): Penurunan Kadar Sex Hormone-Binding Globulin Serum (SHBG) pada Pasien Polycystic Ovarian Syndrome Patients (PCOS) Zahra, Azalia Talitha Saleh, M. Irsan Hafy, Zen Effendi, Yusuf Maritska, Ziske Liberty, Iche Andriyani PCOS Serum SHBG Level Kadar Serum SHBG ABSTRACT Classic symptoms of PCOS including irregular menstruation, high serum androgen concentration, hirsutism, and infertility or subfertility. Low serum sex hormon binding globulin (SHBG) may cause increase of free serum androgen which in turn may cause ovarian dysfunction and clinical symptoms associated with hyperandrogenism. This study aims to look the difference of serum SHBG concentration in PCOS patients and healthy control in Palembang, South Sumatra. This was a case-control study involved 36 PCOS patients and 36 healthy controls. Patient serum was collected and SHBG concentration was conducted using ELISA according to manufacturer instruction. Median serum SHBG concentration in PCOS case group was 152.524 nmol/L (min. 5.756 nmol/L, max. 1539.383 nmol/L). meanwhile, median serum SHBG concentration in control group was 971.449 nmol/L (min. 114.479 nmol/L, max. 1944.036 nmol/L). The difference was found to be statistically significant, with p < 0.001 according to Mann-Whitney test. It is to be concluded that serum SHBG concentration is significantly lower in PCOS patient group compared to healthy control. ABSTRAK Gejala khas PCOS berupa berupa haid tidak teratur, kadar androgen serum yang tinggi, hirsutisme, dan infertilitas atau subfertilitas. Kadar sex hormon binding globulin serum yang rendah menyebabkan peningkatan kadar androgen bebas di serum yang dapat menyebabkan disfungsi ovarium dan gejala klinis yang terkait hiperandrogenisme. Penelitian ini bertujuan untuk melihat perbedaan kadar SHBG serum pada pasien PCOS dan kontrol sehat di Palembang, Sumatra Selatan. Penelitian ini menggunakan metode case control dengan sampel 36 pasien PCOS dan 36 kontrol sehat. Serum darah pasien diambil dan kadar SHBG diperiksa menggunakan ELISA sesuai instruksi pembuat. Kadar SHBG median pada kelompok kasus PCOS adalah 152,524 nmol/L (min. 5,756 nmol/L, maks. 1539,383 nmol/L). sementara itu, kadar SHBG median pada kelompok kontrol adalah 971,449 nmol/L (min. 114,479 nmol/L, maks. 1944,036 nmol/L). Perbedaan tersebut bermakna secara statistik dengan p< 0,001 dengan uji Mann-Whitney. Dapat disimpulkan bahwa kadar SHBG serum pada subjek dengan PCOS lebih rendah secara bermakna dibandingkan dengan kelompok kontrol. Universitas Muhammadiyah Surakarta 2023-02-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://journals2.ums.ac.id/index.php/biomedika/article/view/1744 10.23917/biomedika.v15i1.1744 Biomedika; Vol 15, No 1 (2023): Biomedika Februari 2023; 13-17 2541-2582 2085-8345 eng https://journals2.ums.ac.id/index.php/biomedika/article/view/1744/538 https://creativecommons.org/licenses/by/4.0 |
| spellingShingle | PCOS Serum SHBG Level Kadar Serum SHBG Zahra, Azalia Talitha Saleh, M. Irsan Hafy, Zen Effendi, Yusuf Maritska, Ziske Liberty, Iche Andriyani DECREASED SEX HORMONE-BINDING GLOBULIN (SHBG) SERUM LEVEL IN POLYCYSTIC OVARIAN SYNDROME PATIENTS (PCOS): Penurunan Kadar Sex Hormone-Binding Globulin Serum (SHBG) pada Pasien Polycystic Ovarian Syndrome Patients (PCOS) |
| title | DECREASED SEX HORMONE-BINDING GLOBULIN (SHBG) SERUM LEVEL IN POLYCYSTIC OVARIAN SYNDROME PATIENTS (PCOS): Penurunan Kadar Sex Hormone-Binding Globulin Serum (SHBG) pada Pasien Polycystic Ovarian Syndrome Patients (PCOS) |
| title_full | DECREASED SEX HORMONE-BINDING GLOBULIN (SHBG) SERUM LEVEL IN POLYCYSTIC OVARIAN SYNDROME PATIENTS (PCOS): Penurunan Kadar Sex Hormone-Binding Globulin Serum (SHBG) pada Pasien Polycystic Ovarian Syndrome Patients (PCOS) |
| title_fullStr | DECREASED SEX HORMONE-BINDING GLOBULIN (SHBG) SERUM LEVEL IN POLYCYSTIC OVARIAN SYNDROME PATIENTS (PCOS): Penurunan Kadar Sex Hormone-Binding Globulin Serum (SHBG) pada Pasien Polycystic Ovarian Syndrome Patients (PCOS) |
| title_full_unstemmed | DECREASED SEX HORMONE-BINDING GLOBULIN (SHBG) SERUM LEVEL IN POLYCYSTIC OVARIAN SYNDROME PATIENTS (PCOS): Penurunan Kadar Sex Hormone-Binding Globulin Serum (SHBG) pada Pasien Polycystic Ovarian Syndrome Patients (PCOS) |
| title_short | DECREASED SEX HORMONE-BINDING GLOBULIN (SHBG) SERUM LEVEL IN POLYCYSTIC OVARIAN SYNDROME PATIENTS (PCOS): Penurunan Kadar Sex Hormone-Binding Globulin Serum (SHBG) pada Pasien Polycystic Ovarian Syndrome Patients (PCOS) |
| title_sort | decreased sex hormone binding globulin shbg serum level in polycystic ovarian syndrome patients pcos penurunan kadar sex hormone binding globulin serum shbg pada pasien polycystic ovarian syndrome patients pcos |
| topic | PCOS Serum SHBG Level Kadar Serum SHBG |
| topic_facet | PCOS Serum SHBG Level Kadar Serum SHBG |
| url | https://journals2.ums.ac.id/index.php/biomedika/article/view/1744 |
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